EFFECTS OF CAFFEINE ON LEARNING AND MEMORY IN RATS TESTED IN THE MORRIS WATER MAZE.

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EFFECTS OF CAFFEINE ON LEARNING AND MEMORY IN RATS TESTED IN THE MORRIS WATER MAZE.

ABSTRACT

We studied some of the characteristics of the improving effect of the non-specific adenosine receptor antagonist, caffeine, using an animal model of learning and memory. Groups of 12 adult male Wistar rats receiving caffeine (0.3-30 mg/kg, ip, in 0.1 ml/100 g body weight) administered 30 min before training, immediately after training, or 30 min before the test session were tested in the spatial version of the Morris water maze task. Post-training administration of caffeine improved memory retention at the doses of 0.3-10 mg/kg (the rats Key words.

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