PhD THESIS UROLOGY TOPICS AND MATERIALS

PhD THESIS UROLOGY TOPICS AND MATERIALS

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PhD THESIS UROLOGY TOPICS AND MATERIALS

PhD Research Topics in Urology

A. Pediatric Urology (1–20)

1. Early Versus Delayed Surgical Intervention in Posterior Urethral Valves: Long-term Renal and Bladder Outcomes.
2. Genomic Predictors of Congenital Obstructive Uropathy in Infants.
3. Longitudinal Assessment of Renal Function Decline in Children with Vesicoureteral Reflux.
4. Neurogenic Bladder in Children: Emerging Biomarkers for Early Detection of Renal Impairment.
5. Influence of Maternal Factors on the Incidence of Congenital Urological Anomalies.
6. Machine Learning Models for Predicting Pediatric UTI Recurrence.
7. Defining Optimal Surgical Approaches for Complex Hypospadias Repair: A Multicenter Study.
8. Long-term Quality of Life in Children Treated for Wilms Tumor.
9. Pediatric Urolithiasis: Metabolic and Dietary Determinants Across Different Populations.
10. Immunological Pathways in Pediatric Interstitial Cystitis.
11. Ultrasound Elastography for Early Predicting Pediatric Renal Fibrosis.
12. Genetic Basis of Bladder Exstrophy and Epispadias Complex.
13. Determinants of Renal Scarring Following Recurrent Pediatric UTIs.
14. Comparative Outcomes of Prenatal Versus Postnatal Management of Hydronephrosis.
15. Epidemiology of Pediatric Acute Kidney Injury Secondary to Urological Disorders.
16. Predictors of Incontinence After Pediatric Lower Urinary Tract Reconstruction.
17. Biomechanics of Pediatric Urethral Stricture Formation.
18. Psychosocial Implications of Childhood Urinary Incontinence Into Adolescence.
19. Advanced Imaging Techniques for Detecting Early Renal Deterioration in Pediatric Obstruction.
20. Nutrigenomic Influences on Pediatric Stone Formation.

B. Urologic Oncology (21–45)

• Circulating Tumor DNA (ctDNA) as a Biomarker for Early Detection of Prostate Cancer.
• Genomic Profiling of High-risk Prostate Cancer in African Populations.
• AI-enhanced MRI for Accurate Localization and Grading of Prostate Tumors.
• The Role of Microbiome Dysbiosis in Prostate Cancer Progression.
• Molecular Predictors of Response to Androgen Deprivation Therapy.
• Immunotherapy Resistance Patterns in Advanced Bladder Cancer.
• Long-term Outcomes of Organ-sparing versus Radical Surgery in Bladder Cancer Patients.
• Gene Editing (CRISPR) for Modeling Renal Cell Carcinoma.
• Identification of Epigenetic Markers for Early Renal Cell Carcinoma Detection.
• Racial Disparities in Prostate Cancer Mortality: Molecular and Socioeconomic Interactions.
• Proteomic Signatures Associated With Metastatic Prostate Cancer.
• Evaluation of Nanoparticle-based Drug Delivery in Urologic Cancers.
• Multi-omics Approach for Predicting Bladder Cancer Recurrence.
• Environmental Exposures and Their Role in Urologic Cancer Development.
• Radiogenomics in Urologic Cancer Staging and Prognostication.
• Predictive Value of PSA Derivatives in Aggressive Prostate Cancer.
• Cost-effectiveness Analysis of Prostate Cancer Screening Strategies in Africa.
• Machine Learning Models for Predicting Survival in Renal Cell Carcinoma.
• Impact of Nephron-sparing Surgery on Survival and Quality of Life in Renal Tumor Patients.
• Immunogenetic Basis of Resistance to BCG Therapy in Bladder Cancer.
• Sperm DNA Fragmentation in Testicular Cancer Survivors.
• Targeting Tumor Microenvironment Signaling in Renal Cancer Progression.
• Health System Barriers to Early Detection of Urologic Malignancies.
• Predicting Metastasis in Penile Cancer Using Genomic Biomarkers.
• Comparative Genomics of Transitional Cell Carcinoma Between African and Western Populations.

C. Nephrology–Urology Intersection (46–60)

• Predictors of Chronic Kidney Disease Progression in Obstructive Uropathy.
• Mechanisms of Renal Fibrosis Development After Relief of Urinary Obstruction.
• Biomarkers for Early Detection of Post-Obstructive Renal Injury.
• Evaluating Ureteral Stents: Comparative Study of Novel Biomaterials in Reducing Encrustation.
• AI-assisted Diagnosis of Hydronephrosis via ultrasound imaging.
• Metabolic Pathways in Recurrent Kidney Stone Disease.
• Microbiome Composition in Patients With Recurrent Nephrolithiasis.
• Predictors of Renal Recovery After Acute Obstructive Injury.
• Dietary Sodium and Calcium Metabolism in Stone Formers: A Genomic Perspective.
• Determinants of Renal Atrophy in Chronic Obstructive Uropathy.
• Imaging Biomarkers of Renal Perfusion in Upper Tract Obstruction.
• Oxidative Stress Mechanisms in Kidney Stone Pathophysiology.
• Long-term Renal Outcomes of Patients Undergoing Reconstructive Urological Surgery.
• Gender Differences in Physiology and Pathophysiology of Nephrolithiasis.
• Urinary Exosomes as Biomarkers of Renal Obstruction and Injury.

D. Male Reproductive Health and Sexual Medicine (61–80)

• Molecular Determinants of Idiopathic Male Infertility.
• Environmental Toxins and Their Impact on Sperm DNA Integrity.
• Testicular Microbiome Profiling in Infertile Men.
• Predictive Markers for Varicocele-associated Infertility.
• DNA Methylation Patterns in Men With Non-obstructive Azoospermia.
• Erectile Dysfunction as a Marker of Cardiovascular Disease in Young Adults.
• Patterns of Male Infertility in Sub-Saharan Africa: A Genetic Perspective.
• Hormonal Influences on Testicular Failure in Aging Men.
• Role of Oxidative Stress in Erectile Dysfunction and Response to Therapy.
• Clinical Outcomes of Novel Regenerative Therapies for Erectile Dysfunction.
• Fertility Preservation Strategies in Male Cancer Survivors.
• Psychosexual Impact of Peyronie’s Disease on Affected Men.
• Testicular Ultrasound Elastography as a Diagnostic Tool in Male Infertility.
• Immunological Infertility: Mechanisms and Clinical Correlates.
• Impact of Metabolic Syndrome on Semen Quality.
• Post-vasectomy Pain Syndrome: Pathophysiology and Predictive Factors.
• Long-term Outcomes of Microsurgical Techniques in Male Infertility Treatment.
• Biomarkers of Sperm Mitochondrial Dysfunction in Infertility.
• Sexual Dysfunction in Men With Chronic Urological Conditions.
• Genetic Factors in Persistent Müllerian Duct Syndrome.

E. Surgical Urology and Innovations (81–95)

• Robotic-assisted versus Conventional Laparoscopy in Urologic Surgeries: Outcomes and Learning Curves.
• Development of AI-assisted Surgical Navigation for Endourology.
• Machine Vision for Intraoperative Identification of Ureteric Structures.
• Evaluating 3D-printed Models in Preoperative Planning for Complex Renal Tumors.
• Predictive Models for Postoperative Complications in Major Urologic Surgery.
• Optimization of Postoperative Pain Control in Urologic Surgery Through Multimodal Techniques.
• Heat-mapping Ureteroscopic Laser Techniques to Reduce Tissue Injury.
• Long-term Effects of Urethral Reconstruction Techniques on Sexual Function.
• Evaluating Biodegradable Ureteral Stents: A Clinical Trial.
• Predictors of Failure in Minimally Invasive Stone Surgery.
• Simulation-based Training Models for Enhancing Surgical Skills in Urology Residents.
• Organ-preserving Approaches for High-complexity Renal Tumors.
• Surgical Outcomes of Complex Urethral Stricture Reconstruction.
• Intraoperative Fluorescence Imaging to Improve Tumor Resection Margins.
• Development of Novel Anti-encrustation Coatings for Ureteral Stents.

F. Epidemiology, Health Systems, and Global Urology (96–100)

• Global Burden of Urologic Diseases: A Multi-country Comparative Study.
• Health System Determinants of Delayed Presentation of Urological Cancers in Low-income Countries.
• Socioeconomic Predictors of Health-seeking Behavior in Urologic Symptoms.
• Evaluating Access to Urological Care Among Rural Populations.
• Economic Burden of Chronic Urological Disorders on Households and Healthcare Systems.