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A REVIEW OF TUMOR NECROSIS FACTOR-ALPHA AND INTERLEUKIN 10 AMONG DIABETIC PATIENTS ATTENDING TERTIARY HEALTH CLINIC
Abstract:
This study investigates the levels of Tumor Necrosis Factor Alpha (TNF-α) and Interleukin 10 (IL-10) in diabetic patients seeking medical care at a tertiary health clinic. Diabetes, a chronic metabolic disorder, is associated with systemic inflammation, and cytokines play a pivotal role in the intricate immunological mechanisms underlying this condition. Using a cross-sectional approach, blood samples from diabetic patients are analyzed to measure the concentrations of TNF-α, known for its pro-inflammatory effects, and IL-10, recognized for its anti-inflammatory properties. The study aims to elucidate the interplay between these cytokines in the context of diabetes, offering insights into the immune responses and potential implications for disease management. The findings contribute to the growing body of knowledge in diabetic pathophysiology and may inform future therapeutic strategies aimed at modulating the immune response in diabetic patients attending tertiary health clinics.
Table of Contents:
1. Introduction
1.1 Background of the Study
1.2 Statement of the Problem
1.3 Objectives of the Study
1.4 Research Questions
1.5 Significance of the Study
1.6 Scope and Limitations
1.7 Definition of Terms
2. Literature Review
2.1 Diabetes Mellitus: An Overview
2.1.1 Types of Diabetes
2.1.2 Prevalence and Epidemiology
2.2 Immunological Aspects of Diabetes
2.3 Cytokines in Diabetes
2.3.1 Tumor Necrosis Factor Alpha (TNF-α)
2.3.2 Interleukin 10 (IL-10)
2.4 Previous Studies on TNF-α and IL-10 in Diabetes
2.5 Rationale for the Current Study
3. Research Methodology
3.1 Study Design
3.2 Participants
3.2.1 Inclusion Criteria
3.2.2 Exclusion Criteria
3.3 Sampling Techniques
3.4 Data Collection
3.4.1 Blood Sample Collection
3.4.2 Laboratory Analysis
3.5 Statistical Analysis
4. Tumor Necrosis Factor Alpha (TNF-α) in Diabetic Patients
4.1 TNF-α Levels in Diabetic Patients
4.2 Correlation with Disease Severity
4.3 Impact on Diabetic Complications
5. Conclusion
5.1 Summary of Findings
5.2 Contributions to Knowledge
5.3 Recommendations for Future Research
References
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