HEPATIC ACTIVITY OF METHANOL EXTRACT OF COSTUS LUCANUSIASUS IN WISTAR RATS

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HEPATIC ACTIVITY OF METHANOL EXTRACT OF COSTUS LUCANUSIASUS IN WISTAR RATS

ABSTRACT

The use of medical plants as raw materials in the production of new drugs is ever increasing because of their potentials

in combating the problem of drug resistance in microorganisms. The study was aimed at determining quantitative phytochemicals and essential oil constituents of costus lucanusianus stem (spiral ginger). Quantitative phytochemicals and essential oil constituents were determined using high performance liquid chromatography (HPLC) and Gas

chromatography mass spectrometry (GC- MS) respectively. Result revealed in decreasing order total saponins (837.38mg/100g) with predominant diosgenin (533.83mg/100g), total tannins (485mg/100g), total flavonoids

(261.31mg/100g) with myricetin (138.98mg/100g) as highest, glycosides (51.57mg/100g) with costusoside (25.99mg/100g) as highest, total carotenoids (44.20mg/100g) with carotene (15mg/100g) as highest and lycopene the lowest (3.39×10-6mg/100g) total phytosterol (26.97mg/100g) with sitosterol (18.12mg/100g) as highest phenolics

(22.46mg/100g) ferulic (5.00mg/100g) was highest, total isoflavone was (16.96mg/100g), with daidᴢein (5.39mg/100g) being highest others includes anthocyanins (7.73mg/100g), anthroquinone (1.90mg/100g), total terpinoids (0.91mg/100g), total lignin (0.36mg/100g) and total alkaloids was (0.19mg/100g). Essential oil constituents

included cis-carvone oxide (3.17g/100mg), Trans geranyl acetate (2.17g/100mg), linanyl acetate (1.26g/100mg), βmycrene (1.83g/100mg), ɒ-pinene (1.03g/100mg) and carvone and p-acetyl toluene were the least (0.01g/100mg). costus lucanusianus stem is rich in phytochemicals hence could serve as herbal agents in pharmaceutical and cosmetic industries.

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